Program Initiatives

Reference Epigenome Mapping Centers

This initiative is being issued as a cooperative agreement (U01) to support reference epigenome production centers that will develop reference epigenomes of a variety of human cells.

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Epigenomics Data Analysis and Coordination Center (EDAAC)

This cooperative agreement (U01) will fund the Epigenomics Data Analysis and Coordination Center (EDACC), which will provide data analysis and coordination for all of the Reference Epigenome Mapping Centers.

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Technology Development in Epigenomics

This initiative will support technology development in two important areas of epigenetics research.

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Discovery of Novel Epigenetic Marks in Mammalian Cells

This initiative will support research to identify stable, long term changes in epigenetic processes and establish the utility of these marks in mammalian cells. More Epigenomics of Human Health and Disease

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Epigenomics of Human Health and Disease

This initiative will support research on fundamental epigenomic changes or mechanisms underlying specific diseases; conditions of development or aging; or response to exposures (physical, chemical, behavioral, and social factors).

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Overview of the Roadmap Epigenomics Project

Epigenetics is an emerging frontier of science that involves the study of changes in the regulation of gene activity and expression that are not dependent on gene sequence.

For purposes of this program, epigenetics refers to both heritable changes in gene activity and expression (in the progeny of cells or of individuals) and also stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable. While epigenetics refers to the study of single genes or sets of genes, epigenomics refers to more global analyses of epigenetic changes across the entire genome.

The overall hypothesis of the NIH Roadmap Epigenomics Program is that the origins of health and susceptibility to disease are, in part, the result of epigentic regulation of the genetic blueprint. Specifically, epigenetic mechanisms that control stem cell differentiation and organogensis contribute to the biological response to endogenous and exogenous forms of stimuli that result in disease.