Roadmap Epigenomics Project

Program Initiatives

Reference Epigenome Mapping Centers

This initiative is being issued as a cooperative agreement (U01) to support reference epigenome production centers that will develop reference epigenomes of a variety of human cells.

Epigenomics Data Analysis and Coordination Center (EDAAC)

This cooperative agreement (U01) will fund the Epigenomics Data Analysis and Coordination Center (EDACC), which will provide data analysis and coordination for all of the Reference Epigenome Mapping Centers.

Technology Development in Epigenomics

This initiative will support technology development in two important areas of epigenetics research.

Discovery of Novel Epigenetic Marks in Mammalian Cells

This initiative will support research to identify stable, long term changes in epigenetic processes and establish the utility of these marks in mammalian cells. More Epigenomics of Human Health and Disease

Epigenomics of Human Health and Disease

This initiative will support research on fundamental epigenomic changes or mechanisms underlying specific diseases; conditions of development or aging; or response to exposures (physical, chemical, behavioral, and social factors).

Discovery of Novel Epigenetic Marks in Mammalian Cells

This initiative will support research to identify stable, long term changes in epigenetic processes and establish the utility of these marks in mammalian cells. It is anticipated that the results of these studies would quickly be translated to global epigenome mapping in human cells (conducted by the Reference Epigenome Mapping Centers). Epigenetic processes are critical to the normal development and function of multicellular organisms. Understanding these processes and in particular their susceptibility to perturbation may provide novel insights into disease pathogenesis and therapeutic approaches. This initiative will be launched under two separate RFAs – an R01 (research project) and an R21 (exploratory/developmental project) – both of which are due to release in Fall 2007, with funding expected to begin in Fall 2008.