Discovery of Novel Epigenetic Marks in Mammalian Cells
This initiative will support research to identify stable, long term changes in epigenetic processes and establish the utility of these marks in mammalian cells. It is anticipated that the results of these studies would quickly be translated to global epigenome mapping in human cells (conducted by the Reference Epigenome Mapping Centers). Epigenetic processes are critical to the normal development and function of multicellular organisms. Understanding these processes and in particular their susceptibility to perturbation may provide novel insights into disease pathogenesis and therapeutic approaches. This initiative will be launched under two separate RFAs – an R01 (research project) and an R21 (exploratory/developmental project) – both of which are due to release in Fall 2007, with funding expected to begin in Fall 2008.