Epigenome Mapping Centers

The Roadmap Epigenomics Program is an international collaboration.

Participants & Projects:

Overview:

The Roadmap Epigenomics Program proposes to: (1) create an international committee; (2) develop standardized platforms, procedures, and reagents for epigenomics research; (3) conduct demonstration projects to evaluate how epigenomes change; (4) develop new technologies for single cell epigenomic analysis and in vivo imaging of epigenetic activity; and (5) create a public data resource to accelerate the application of epigenomics approaches.

Objectives:

Transforming biomedical research in the following ways:

  • Develop comprehensive reference epigenome maps
  • Develop new technologies for comprehensive epigenomic analyses
A series of five interrelated initiatives are currently being developed under this program.
See below for complete list of program participants. Click the title for more detailed information.

Funded Research

Epigenomics of Human Health and Disease (R01) RFA-RM-08-017
PI Name Institution Name Title

BENNETT, DAVID A.

RUSH UNIVERSITY MEDICAL CENTER Exploring the Role of the Brain Epigenome: Cognitive Decline and Life Experiences

COLEMAN, PAUL D.

SUN HEALTH RESEARCH INSTITUTE DNA methylation in Alzheimer's disease and normally aged brain

CONNELLY, JESSICA J.

UNIVERSITY OF VIRGINIA CHARLOTTESVILLE Epigenomics of Atherosclerosis

EINSTEIN, FRANCINE HUGHES (contact)
GREALLY, JOHN
MONTAGNA, CRISTINA

YESHIVA UNIVERSITY Genome-wide DNA Methylation Profiles Associated with Abnormal Intrauterine Growth

FALLIN, MARGARET DANIELE (Contact)
FEINBERG, ANDREW P.

JOHNS HOPKINS UNIVERSITY Environment, The Perinatal Epigenome, and Risk for Autism and Related Disorders

GIBBONS, GARY HUGH

MOREHOUSE SCHOOL OF MEDICINE Vascular Epigenome Dynamics in African-American Hypertensives

HUANG, TIM H.-M.

OHIO STATE UNIVERSITY Epigenomics of Bisphenol A Exposure and Disease Risk

KOHWI-SHIGEMATSU, TERUMI

UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB Determinants for genome-wide epigenomics in metastatic breast cancer

LIU, YONGMEI

WAKE FOREST UNIVERSITY HEALTH SCIENCES Epigenome-Wide Association Study of DNA Methylation and Atherosclerosis

MELTZER, STEPHEN J.

JOHNS HOPKINS UNIVERSITY The temporal epigenomic program of Barrett's neoplastic progression

MERBS, SHANNATH L.

JOHNS HOPKINS UNIVERSITY Pangenomic Analysis of DNA Methylation Marks in Glaucoma and Macular Degeneration

MILL, JONATHAN

KING'S COLLEGE LONDON A multi-faceted approach to epigenomic profiling in Alzheimer's disorder

OPHOFF, ROEL A.

UNIVERSITY OF CALIFORNIA LOS ANGELES Epigenetics and disease: the role of DNA methylation in schizophrenia susceptibility

PETRONIS, ART

CENTRE FOR ADDICTION AND MENTAL HEALTH DNA METHYLOME ANALYSIS IN BIPOLAR DISORDER

PFEIFER, GERD P.

CITY OF HOPE/BECKMAN RESEARCH INSTITUTE Aging and the unstable epigenome

ROSEN, EVAN D.

BETH ISRAEL DEACONESS MEDICAL CENTER Epigenomics of Human Insulin Resistance

SCHWARTZ, DAVID ALBERT (contact)
COSGROVE, GREGORY P.
YANG, IVANA VERONA

NATIONAL JEWISH HEALTH Asthma: An Epidemic Caused by Epigenetics?

SULLIVAN, KATHLEEN E.

CHILDREN'S HOSPITAL OF PHILADELPHIA Epigenomics of SLE

SUSZTAK, KATALIN (contact)
GREALLY, JOHN

YESHIVA UNIVERSITY Epigenetics Landscape of Chronic Kidney Disease

TYCKO, BENJAMIN (contact)
MAYEUX, RICHARD

COLUMBIA UNIVERSITY HEALTH SCIENCES Epigenomics of Alzheimer's Disease

YOKOMORI, KYOKO

UNIVERSITY OF CALIFORNIA IRVINE Epigenomic Analysis of Facioscapulohumeral Muscular Dystrophy

YOUNG, RICHARD

WHITEHEAD INSTITUTE FOR BIOMEDICAL RES Epigenomic Mapping in Human Tumor Stem Cells
Reference Epigenome Mapping Centers (U01) RFA-RM-07-013
PI Name Institution Name Title

BERNSTEIN, BRADLEY E (contact)
MEISSNER, ALEXANDER

MASSACHUSETTS INSTITUTE OF TECHNOLOGY Production sequencing of reference human epigenomes

COSTELLO, JOSEPH F (contact)
MARRA, MARCO ANTONIO

UNIVERSITY OF CALIFORNIA SAN FRANCISCO Integrated Epigenetic Maps of Human Embryonic and Adult Cells

REN, BING

LUDWIG INSTITUTE FOR CANCER RESEARCH The San Diego Epigenome Center

STAMATOYANNOPOULOS, JOHN

UNIVERSITY OF WASHINGTON Northwest Reference Epigenome Mapping Center
Epigenomics Data Analysis and Coordination Center – EDACC (U01) RFA-RM-07-014
PI Name Institution Name Title

BEAUDET, ARTHUR L.
MILOSAVLJEVIC, ALEKSANDAR (contact)

BAYLOR COLLEGE OF MEDICINE Epigenomics Data Analysis and Coordination Center at Baylor College of Medicine
Technology Development in Epigenetics (R21) RFA-RM-07-012
PI Name Institution Name Title

BEDFORD, MARK T
GOZANI, OR P (contact)

STANFORD UNIVERSITY Applying peptide and protein domain microarrays to epigenetic research

HANG, HOWARD C

ROCKEFELLER UNIVERSITY Chemical Reporters for the Analysis of Lysine Methylation in Epigenetics

HENIKOFF, STEVEN

FRED HUTCHINSON CANCER RESEARCH CENTER Genome-wide measurement of histone replacement rates: a new dimension in epigenom

KOIDE, SHOHEI

UNIVERSITY OF CHICAGO Novel affinity reagents for epigenetics markers

LIU, RIHE

UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Identification of the Interactome of Methylated Histones from Human Proteome
Technology Development in Epigenetics (R01) RFA-RM-07-011
PI Name Institution Name Title

CRAIGHEAD, HAROLD G
SOLOWAY, PAUL D (contact)

CORNELL UNIVERSITY ITHACA Epigenomic analysis on a nanoscale device

MITRA, ROBI D

WASHINGTON UNIVERSITY METHYLMAP: A TECHNOLOGY TO ANALYZE PROMOTER METHYLATION IN MICRODISSECTED CELLS

SHI, HUIDONG
ZHANG, KUN (contact)

UNIVERSITY OF CALIFORNIA SAN DIEGO Genome-scale anaylsis of DNA methylation in CpG Islands with bisulfite sequencing

TACKETT, ALAN JACKSON (contact)
TAVERNA, SEAN D

UNIVERSITY OF ARKANSAS MED SCIS LTL ROCK Development of technology for high resolution epigenetic profiling of chromatin
Discovery of Novel Epigenetic Marks in Mammalian Cells (R21) RFA-RM-07-016
PI Name Institution Name Title

CHEN, XIAN
STRAHL, BRIAN D (contact)

UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Identification of novel histone modifications in a model eukaryote

WARBURTON, PETER E

MOUNT SINAI SCHOOL OF MEDICINE OF NYU Non-coding RNAs in the epigenetics of human centromere formation
Discovery of Novel Epigenetic Marks in Mammalian Cells (R01) RFA-RM-07-015
PI Name Institution Name Title

CHENG, XIAODONG

EMORY UNIVERSITY Identification and characterization of novel epigenetic marks of non-histone prot

GRANT, PATRICK A

UNIVERSITY OF VIRGINIA CHARLOTTESVILLE Characterization of a novel histone H3 phosphorylation mark in DNA replication

KATZ, RICHARD ALAN

INSTITUTE FOR CANCER RESEARCH Discovery of Epigenetic Marks in Human Cells by High Throughput siRNA Screening

OETTINGER, MARJORIE A

MASSACHUSETTS GENERAL HOSPITAL Is symmetrical dimethylation of Arginine 2 of Histone H3 used as an epigenetic si

TULIN, ALEXEI V
ZARET, KENNETH S (contact)

INSTITUTE FOR CANCER RESEARCH Novel Epigenetic Marks in Mitosis

ZHAO, YINGMING

UNIVERSITY OF TEXAS SW MED CTR/DALLAS Systematic screening for new histone marks